In addition, gender differences have not been given enough attention through available literature. 9 found that MPV in patients with MS was significantly higher compared with the control groups.
And the volunteers of this investigation were only pre-pubertal children. 8 showed that patients with MS had a significantly lower MPV level and this, phenomenon only appeared in females. But, there are controversies about the associations between MPV and MS. These investigations would suggest a high level of MPV as a potential risk factor for MS. Furthermore, some investigations found MS could predispose people to the development of CVD and DM. MPV is associated with a wide variety of diseases such as cardiovascular disease (CVD) and diabetes mellitus (DM) 7. Larger and more reactive PLTs increase the possibility of thrombosis. Other studies have found a positive correlation between PLT aggregation function and mean platelet volume (MPV) 5, 6. Some studies have demonstrated that the levels of hemoglobin, red blood cell (RBC), white blood cell (WBC), and blood platelet (PLT) were higher in adults with MS 4. Getting complete blood count (CBC) is a convenient and affordable way to reveal the hematological status and, can probably provide important information indicating MS. A study reported that 20% of adults in the Western world have MS 3. Metabolic syndrome (MS) means a cluster of cardiometabolic risk factors including elevated blood pressure, central obesity, atherogenic dyslipidemia and impaired glucose metabolism 1, 2. This study indicated that MS was inversely associated with MPV in females only. The odds of having MS were significantly lower in higher MPV quartiles compared with MPV Quartile 1 in women (Adjusted OR < 1, P < 0.01). In females, the prevalence of MS was higher in low MPV group than in high MPV groups. We found women had higher levels of MPV (10.09 vs. Crude odd ratios of MS between MPV quartiles and 95% confidence intervals were analyzed by binary logistic regression in this study. The relationship between sex and MS was evaluated by chi-square tests. The data was grouped by sex and values of data between men and women groups were analyzed by independent sample’s t-test. The mean age of the group was 48.21 years old. We compiled age, body mass index, blood cell counts, MPV, and other data of 59976 self-reported healthy volunteers (28428 male, 31548 female), 24.65% of who have MS. There are close connections among MPV, MS, and cardiometabolic risk. It also evaluates the association between them. The focus of this study was to to investigate MPV values in patients with and without metabolic syndrome (MS). Mean platelet volume (MPV) is a determinant of activation and variability of platelets (PLT).